Evaluating Selenium Supplementation in Gestational Diabetes Mellitus: Insights from a Systematic Review and Meta-Analysis

Highlight

• Selenium supplementation at 200 µg/day significantly reduces fasting plasma glucose levels in women with gestational diabetes mellitus (GDM).
• Reduced incidence of newborn hyperbilirubinemia was observed with selenium supplementation.
• Selenium did not significantly impact insulin resistance as measured by HOMA-IR or lipid profiles including total cholesterol, triglycerides, LDL-C, and HDL-C.
• Current evidence draws from a limited number of randomized controlled trials, warranting cautious interpretation and need for further validation.

Study Background