Revealing Brain Connectivity Disruptions to Predict Long-Term Seizure Recurrence After Temporal Lobe Epilepsy Surgery
brain network hubstemporal lobe epilepsySeizure recurrenceMRI connectomicssurgical outcomessurgical outcomes
Highlight
- Long-term seizure recurrence after temporal lobe epilepsy surgery is linked to disruption in brain network hubs, notably the hippocampi and dorsal attention network.
- Combining structural and functional MRI-derived connectomes enhances the accuracy of predicting seizure recurrence over clinical variables alone.
- Machine learning models using normative hub disruption metrics demonstrate high specificity and have potential for clinical risk stratification post-surgery.
- Identified biomarkers indicate seizure recurrence drivers may extend beyond resected temporal regions, suggesting broader network involvement.
Study Background
MedXY registered readers
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.