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Rethinking Hemodynamics in Aortic Stenosis: The Paradoxical Normal-Flow, Low-Ejection Fraction Phenotype and Post-TAVI Outcomes

MedXY Editorial Team•Jan 22, 2026•Cardiology
aortic stenosishemodynamicsleft ventricular ejection fractionTAVI

Highlights of the COMPARE-TAVI 1 Substudy

Among the key takeaways from the analysis of the COMPARE-TAVI 1 trial are the following:

1. A distinct phenotype of severe aortic stenosis (AS) exists, characterized by a normal stroke volume index (SVi ≥35 mL/m2) despite a reduced left ventricular ejection fraction (LVEF <50%), occurring in approximately 10.7% of patients undergoing transcatheter aortic valve implantation (TAVI).

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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