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Refining HbA1c Thresholds for Accurate Type 1 Diabetes Progression Risk in Islet Autoantibody-Positive Adults

MedXY Editorial Team•Jul 12, 2026•Diabetes & Endocrinology
autoantibodiesHbA1crisk stratificationtype 1 diabetes

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The accuracy of HbA1c thresholds to predict type 1 diabetes progression in islet autoantibody-positive adults improves when accounting for age-related increases in HbA1c. Traditional thresholds tend to overestimate risk in adults compared to children. Applying an age-adjusted HbA1c or a higher fixed threshold (≥6.0% [42 mmol/mol]) better aligns progression risk across age groups, particularly among those aged 30 and older.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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