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Diabetes & Endocrinology

Preserved Endogenous Insulin Production Significantly Reduces Diabetic Ketoacidosis Risk in Type 1 Diabetes

MedXY Editorial TeamSep 8, 2026
type 1 diabetesEndogenous InsulinC-peptide

Highlight

  • Detectable stimulated C-peptide (>0.2 nmol/mL) reflects endogenous insulin production in type 1 diabetes.
  • Residual C-peptide is strongly associated with a markedly reduced risk of diabetic ketoacidosis (DKA).
  • Over 99% of DKA episodes occurred when C-peptide levels were low or undetectable.
  • Preserving beta-cell function may offer a critical therapeutic target to mitigate DKA risk long term.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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