Pre-Diagnostic Low-Normal Immunoglobulin Levels Identify Early Clonal B-cell Dysregulation and CLL Susceptibility: Insights from a Large Retrospective Cohort
cancer susceptibilityimmunoglobulin levelsmonoclonal B-cell lymphocytosis慢性淋巴细胞白血病，免疫球蛋白水平，单克隆 B 细胞淋巴细胞增多症，癌症易感性
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This large retrospective cohort study of nearly 295,000 adults reveals distinct predictive roles for low-normal immunoglobulin levels in the development of chronic lymphocytic leukemia (CLL). Low-normal serum IgA uniquely identifies constitutional susceptibility to CLL, while low-normal IgM and IgG reflect prediagnostic tumor burden linked to occult monoclonal B-cell lymphocytosis (MBL). These dual mechanisms provide novel insights into CLL pathogenesis and risk stratification years before clinical diagnosis.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.