Multifunctional Dietary Approach to Reduce Intestinal Inflammation in Cardiometabolic Risk Subjects: Insights from the SINFONI Project

The increasing prevalence of cardiometabolic (CM) diseases, which include conditions such as obesity, diabetes, and cardiovascular disease, raises significant public health concerns. These diseases are often associated with chronic low-grade inflammation, a process that can be influenced by various factors, most notably alterations in gut microbiota (GM) and compromised intestinal barrier integrity. The SINFONI project emerged to investigate a multifunctional (MF) nutritional strategy aimed at modulating inflammation and GM composition through the inclusion of diverse bioactive compounds in the diet.

Study Overview

In this randomized crossover-controlled study, 30 individuals identified as being at risk for cardiometabolic diseases participated in a dietary intervention over a period of 2 months. Participants consumed MF cereal products enriched with key bioactive components such as polyphenols, fibers, slowly digestible starch, and omega-3 fatty acids. In contrast, a control group consumed cereal products without any bioactive compounds.