Lymph Node Assessment and Survival Outcomes in Favorable Histology Wilms Tumor: Insights from a Large COG Renal Tumor Study

Highlight

– Lymph node (LN) positivity negatively impacts event-free survival (EFS) in stage I to III favorable histology Wilms tumor (FHWT).
– The total number of lymph nodes sampled is associated with overall survival (OS) in LN-negative patients.
– Neither the number of positive lymph nodes nor lymph node density predicts survival outcomes in LN-positive stage III patients.
– Findings emphasize the urgent need for standardized lymph node sampling protocols in FHWT surgical staging.

Study Background