Impact of Ocular Proton Therapy on Corneal Subbasal Nerve Plexus in Uveal Melanoma: Longitudinal Confocal Microscopy Findings
corneal confocal microscopycorneal nerve fiber densityocular proton therapysubbasal nerve plexusuveal melanoma
Highlight
- Ocular proton therapy (OPT) for uveal melanoma markedly reduces corneal subbasal nerve plexus parameters including nerve fiber density and length.
- The extent of nerve loss correlates with clinical target volume, reflecting radiation exposure levels.
- Despite structural nerve alterations, corneal sensitivity remains largely unchanged over 12-month follow-up.
- Patient-reported symptoms show limited correlation with nerve fiber loss, highlighting a discrepancy between morphological and functional outcomes.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.