Overview
Adult acute myeloid leukemia (AML) with NUP98 rearrangement is a rare but biologically important subgroup of AML. NUP98 is a gene located on chromosome 11 that normally helps regulate transport between the cell nucleus and cytoplasm. When NUP98 becomes rearranged with another gene, the resulting fusion protein can disrupt normal blood cell development and promote leukemia. Although NUP98 rearrangements are often discussed in pediatric leukemia, this study provides one of the largest adult cohorts to date and shows that the disease carries distinct molecular features and a poor overall prognosis.
