Xenotransplantation in Acute Liver Failure: Bridging the Organ Gap with Genetically Modified Porcine Livers

Highlight

• Xenotransplantation with genetically modified porcine livers offers a promising bridge therapy for patients with acute liver failure, addressing the critical organ shortage.
• Recent early clinical cases demonstrate technical feasibility and short-term viability of porcine liver grafts in extracorporeal support and auxiliary transplantation.
• Challenges remain, notably coagulopathy and immune-mediated injury, necessitating further genetic and immunologic refinements.
• Advances in gene editing, organ preservation, and machine perfusion technology underpin these translational breakthroughs.

Study Background