TYK2 Signaling

Targeting TYK2: A Novel Therapeutic Vulnerability in CALR-Mutant Myeloproliferative Neoplasms

This article highlights the discovery that TYK2 kinase is a selective therapeutic target in CALR-mutant myeloproliferative neoplasms, with combined TYK2 and JAK2 inhibition offering enhanced efficacy over JAK2 inhibition alone.