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Decoding ATRA Resistance in Acute Promyelocytic Leukemia: The Role of PML::RARA Mutations Enhancing Basal Repression
Hematology-Oncologytranscriptional repressionAcute Promyelocytic Leukemia

Decoding ATRA Resistance in Acute Promyelocytic Leukemia: The Role of PML::RARA Mutations Enhancing Basal Repression

By MedXY|Aug 24, 2026

A clustered subset of hotspot PML::RARA mutations drives ATRA resistance in acute promyelocytic leukemia by enhancing basal transcriptional repression rather than disrupting transactivation, suggesting novel mechanisms underlying therapeuti

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