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Higher Stroke and TIA Risk With Pulsed Field Ablation Compared to Radiofrequency Ablation in Atrial Fibrillation: Insights From a Large Prospective Registry
Cardiologyatrial fibrillationPulsed-field ablation

Higher Stroke and TIA Risk With Pulsed Field Ablation Compared to Radiofrequency Ablation in Atrial Fibrillation: Insights From a Large Prospective Registry

By MedXY|Aug 27, 2026

This prospective registry reveals a significantly increased risk of stroke or transient ischemic attack within 30 days after pulsed field ablation compared to radiofrequency ablation for atrial fibrillation, highlighting important safety co

Boston Scientific Cuts 2026 Guidance Again as Watchman, Electrophysiology Businesses Struggle
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Pulsed-field ablation
Electrophysiology

Boston Scientific Cuts 2026 Guidance Again as Watchman, Electrophysiology Businesses Struggle

By MedXY|Jul 29, 2026

Boston Scientific slashed its 2026 sales and EPS forecasts for the second straight quarter, citing competitive pressure in pulsed field ablation and declining standalone Watchman procedures.

Pulsed Field Ablation Versus Sham Procedure in Atrial Fibrillation: Insights from the PFA-SHAM Randomized Clinical Trial
Cardiologyatrial fibrillationPulsed-field ablation

Pulsed Field Ablation Versus Sham Procedure in Atrial Fibrillation: Insights from the PFA-SHAM Randomized Clinical Trial

By MedXY|Jul 1, 2026

This sham-controlled trial demonstrates that pulsed field ablation significantly reduces atrial fibrillation recurrence, burden, and improves quality of life and psychological distress compared to sham treatment.

High-Repetition-Frequency Nanosecond Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: 12-Month Outcomes From the SCENA-AF Trial
Cardiologyatrial fibrillationPulsed-field ablation

High-Repetition-Frequency Nanosecond Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: 12-Month Outcomes From the SCENA-AF Trial

By MedXY|Mar 3, 2026

The SCENA-AF trial highlights the efficacy of nanosecond pulsed field ablation (nsPFA) for treating paroxysmal atrial fibrillation, achieving an 88.49% success rate at 12 months with minimal complications and a significant shift toward loca

High-Voltage Focal Pulsed Field Ablation Achieves Transmurality and 98% Reduction in Scar-Related Ventricular Tachycardia
CardiologyElectrophysiologyPulsed-field ablation

High-Voltage Focal Pulsed Field Ablation Achieves Transmurality and 98% Reduction in Scar-Related Ventricular Tachycardia

By MedXY|Jan 18, 2026

The first-in-human VCAS trial demonstrates that high-voltage focal pulsed field ablation (PFA) safely delivers transmural lesions in thick ventricular scar tissue, significantly reducing ventricular tachycardia burden by 98% in high-risk pa

Nanosecond Pulsed Field Ablation Matches Radiofrequency Efficacy While Slashing Procedure Time: Insights From the InsightPFA Trial
Cardiologyatrial fibrillationElectrophysiology

Nanosecond Pulsed Field Ablation Matches Radiofrequency Efficacy While Slashing Procedure Time: Insights From the InsightPFA Trial

By MedXY|Dec 26, 2025

The InsightPFA trial confirms that a novel nanosecond pulsed field ablation (nsPFA) system is noninferior to radiofrequency ablation for paroxysmal atrial fibrillation, significantly reducing procedure and left atrial dwell times while main

Pulsed Field Ablation Demonstrates Exceptional Safety in Real-World Practice: Insights from the 40,000-Patient MANIFEST-US Study
Cardiologyatrial fibrillationpatient safety

Pulsed Field Ablation Demonstrates Exceptional Safety in Real-World Practice: Insights from the 40,000-Patient MANIFEST-US Study

By MedXY|Dec 25, 2025

The MANIFEST-US study of over 40,000 patients confirms that pulsed field ablation (PFA) for atrial fibrillation maintains a high safety profile in real-world U.S. clinical practice, with a major complication rate of just 0.63% and a complet

ADVANTAGE AF Phase 2: Evaluating Pulsed Field Ablation for Persistent Atrial Fibrillation Using Continuous ECG Monitoring
CardiologyPulsed-field ablation

ADVANTAGE AF Phase 2: Evaluating Pulsed Field Ablation for Persistent Atrial Fibrillation Using Continuous ECG Monitoring

By MedXY|Oct 3, 2025

The ADVANTAGE AF Phase 2 study demonstrates pulsed field ablation’s safety and efficacy for persistent atrial fibrillation, introducing continuous cardiac monitoring to better assess arrhythmia burden and outcomes over one year.

Optimizing Sedation for Pulsed-Field Ablation in Atrial Fibrillation: Results of the COOPERATIVE-PFA Trial
CardiologyAnesthesiaatrial fibrillation

Optimizing Sedation for Pulsed-Field Ablation in Atrial Fibrillation: Results of the COOPERATIVE-PFA Trial

By MedXY|Oct 3, 2025

This randomized trial compares sedation regimens for pulsed-field ablation in atrial fibrillation, finding remimazolam-ketamine deep analgosedation superior to propofol-opioid approaches in reducing hypoxemia and hypotension.

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