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Genomic testing holds promise for guiding preventive strategies in psychiatry, particularly in high-risk and clinically uncertain contexts; however, current evidence supports targeted rather than universal approaches.
A large U.S. cohort study found higher rates of postpartum psychiatric conditions after planned or unplanned cesarean delivery, but not after successful operative vaginal delivery, highlighting the need for closer postpartum mental health f
Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.
A comprehensive meta-analysis of longitudinal studies involving over 540,000 participants reveals that spirituality and religious involvement are associated with a 13-18% reduction in harmful alcohol and drug use, offering significant impli
This large-scale case-control study examines how polygenic risk scores for suicide attempt intersect with clinical traits and environmental stressors. Findings indicate that genetic liability significantly correlates with aggression, depres
A landmark case-control study identifies significant associations between polygenic risk scores for suicide attempts and specific clinical traits, including aggression and depression severity, while also highlighting the interplay between g
A systematic review and meta-analysis of 12 clinical trials reveals that the quantity of preparation therapy—not post-dose integration—significantly predicts depressive symptom reduction in psychedelic-assisted therapy, highlighting the cri
This Swedish population-based study examines the complex relationship between depression and criminal convictions, revealing that neighborhood social structure and familial confounding significantly influence this association, with varying
A longitudinal study published in NEJM AI evaluates seven generative AI chatbots for alcohol misuse support, finding that while they excel in empathy and non-judgmental language, they frequently provide low-quality or inaccurate medical inf
A large-scale randomized controlled trial reveals that online self-help programs, featuring either automated or individualized psychological support, significantly reduce the mental health burden on informal caregivers of people with depres
A randomized clinical trial published in JAMA Psychiatry reveals that yoga as an adjuvant to buprenorphine significantly shortens opioid withdrawal stabilization time and restores autonomic balance, offering a neurobiologically informed str
A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive per
A landmark network meta-analysis demonstrates that slow antidepressant tapering (>4 weeks) combined with psychological support is as effective as drug continuation in preventing relapse, providing a safe, evidence-based pathway for patie
In two large Alzheimer cohorts, a history of depression, anxiety, or PTSD and an increased number of psychiatric comorbidities were associated with earlier age at AD symptom onset by up to ~7–8 years for multi-morbidity.
Massachusetts General Hospital leads the 2025-2026 US News psychiatric hospital rankings. Rankings highlight excellence in psychiatric care, but methodological nuances and clinical implications warrant closer examination.