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This study reveals bidirectional mediation between BMI and inflammatory markers affecting embryo quality and availability in PCOS women undergoing ART, highlighting BMI’s predominant role.
Saroglitazar significantly improves liver fat content, liver enzymes, and lipid profiles in women with PCOS and MASLD, highlighting its potential as a therapeutic option in this underrepresented population.
A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.
This article explores how 11-oxygenated androgens differ by PCOS phenotypes and respond to first-line therapies, emphasizing their role in phenotyping and guiding treatment in polycystic ovary syndrome.
This review synthesizes current evidence linking adverse childhood experiences with increased risk and features of PCOS, highlighting possible neuroendocrine mechanisms and clinical implications for reproductive health management.
In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.
Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better preg
This study links PCOS-related miscarriage risk to gut microbiome changes, especially reduced Parabacteroides merdae and higher isoleucine, which may promote endometrial senescence and impair pregnancy outcomes.
A retrospective study highlights how 1-hour plasma glucose levels can identify early cardiometabolic risks in women with PCOS who appear to have normal blood sugar levels.
A cross-sectional study reveals that while MCP1 and FABP4 are elevated in early pregnancy among women with PCOS, these biomarkers primarily reflect maternal adiposity and do not independently predict adverse outcomes, highlighting the impor
Recent evidence reveals that one in four premenopausal women with Type 1 diabetes (T1D) suffers from undiagnosed androgen excess disorders, primarily the classic PCOS phenotype, necessitating routine screening and a recalibration of reprodu
A cross-sectional study reveals that 26% of women with Type 1 Diabetes suffer from undiagnosed androgen excess, primarily PCOS. The findings emphasize the role of iatrogenic hyperinsulinism and advocate for routine screening, especially for
A retrospective study of 1,249 Asian women reveals that those with PCOS maintain superior ovarian reserve and stable cumulative pregnancy rates via ART even after age 36, suggesting PCOS may serve as a biological model for extended reproduc
A 2025 meta-analysis of 19 RCTs (n=1657) found liraglutide combined with metformin improved glycaemia, insulin resistance, BMI, sex hormones and lipids versus metformin alone in overweight or obese women with PCOS; evidence certainty was lo
A 2025 meta-analysis of 19 RCTs (n=1657) found liraglutide combined with metformin improved glycaemia, insulin resistance, BMI, sex hormones and lipids versus metformin alone in overweight or obese women with PCOS; evidence certainty was lo
A large retrospective real‑world cohort (n=4241) of women with PCOS and overweight/obesity treated with tirzepatide experienced mean 18.8% weight loss at 10 months (90% lost ≥10%); digital engagement amplified outcomes. The data are promisi
A 12-week randomized trial demonstrates that combining metformin and nanocurcumin significantly improves lipid metabolism, glucose regulation, hormonal balance, and body metrics in women with PCOS, surpassing effects seen with either agent
Combination therapy with metformin and semaglutide improves weight loss, metabolic parameters, menstrual function, and natural pregnancy rates in overweight/obese women with PCOS compared to metformin alone.
Scientific findings link imbalances in gut microbiota and metabolic markers to pregnancy complications in women with PCOS.
A systematic review assesses sexual function in women with PCOS, revealing impaired psychosexual function and calling for more diverse and comprehensive studies.
