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Ultra-Early Versus Early Vasopressin Initiation After Norepinephrine Escalation in Septic Shock: Insights from a Target Trial Emulation

By MedXY|Aug 12, 2026

This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use

Norepinephrine at Extubation: Challenging the Hemodynamic Safety Paradigm in Critically Ill Patients with Obesity

Anesthesiologycritical care

norepinephrine

Latest news

Ultra-Early Versus Early Vasopressin Initiation After Norepinephrine Escalation in Septic Shock: Insights from a Target Trial Emulation

Norepinephrine at Extubation: Challenging the Hemodynamic Safety Paradigm in Critically Ill Patients with Obesity

Higher Blood Pressure Targets in Septic Shock: When More Vasopressors Do More Harm than Good

Preventing Post‑Induction Hypotension With Low‑Dose Norepinephrine Reduces Postoperative Complications After Major Abdominal Surgery