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In a randomized trial of 316 patients with ischemic stroke/TIA, nonvalvular atrial fibrillation, and atherosclerotic disease, adding an antiplatelet to anticoagulation did not reduce ischemic events but doubled clinically relevant bleeding
The SEGA randomized trial suggests general anesthesia (GA) during endovascular therapy for large‑vessel occlusion stroke may lead to better 90‑day functional outcomes and higher reperfusion rates than moderate sedation, though credible inte
Post hoc analyses of LAAOS III show surgical left atrial appendage occlusion (LAAO) during cardiac surgery lowers the proportion of cardioembolic and cortical infarcts and is associated with less disability and lower early mortality after i
A nationwide Chinese registry analysis reveals no overall benefit of intravenous alteplase in minor ischemic stroke but suggests select subgroups, especially those with disabling symptoms or higher NIHSS scores, may experience improved func
This review synthesizes preclinical evidence on electroacupuncture’s mechanisms in ischemic stroke, highlighting its therapeutic potential and factors influencing efficacy.
The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvem
This study investigates how a history of hypertension influences the effectiveness of combined clopidogrel-aspirin treatment in preventing recurrent strokes after mild ischemic events or high-risk transient ischemic attacks.
Intravenous antihypertensive use within 24 hours after successful EVT in acute ischemic stroke associates with poorer functional outcomes and higher mortality, underscoring the need for cautious blood pressure management strategies post-thr
A multicenter trial assessing emotional and cognitive screening post-ischemic stroke found no improvement in societal participation at 1 year, though modest early benefits in anxiety and quality of life were noted.
This systematic review and meta-analysis evaluates NT-proBNP’s accuracy in predicting mortality among ischemic stroke patients, revealing moderate to high prognostic performance with potential clinical utility in risk stratification.
A subanalysis of the ELAN trial shows that prior reperfusion therapy does not alter the safety or efficacy outcomes of early versus late initiation of direct oral anticoagulants in ischemic stroke patients with atrial fibrillation.
Unexplained early neurologic deterioration (unEND) affects about 10% of ischemic stroke patients after thrombectomy, linked to age, anesthesia, delayed reperfusion, and infarct growth beyond hypoperfused tissue.
Pre-stroke low-dose aspirin in distal medium vessel occlusion stroke patients undergoing mechanical thrombectomy is linked to improved 90-day functional outcomes and reduced mortality without increased symptomatic hemorrhage risk.
This article explores the associations between pregnancy complications and the risk of ischemic stroke in young women, highlighting the importance of early identification for preventive measures.
