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In OPTIMAL-BP 1-year follow-up, targeting systolic BP <140 mm Hg after successful thrombectomy was associated with worse long-term functional recovery than conventional BP management.
Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.
The DISTAL trial found no 12-month disability or survival benefit from adding endovascular treatment to best medical therapy in mild-to-moderate medium or distal vessel occlusion stroke.
A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.
In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.
Subgroup analysis of the OPTIMAS trial reveals that neither the timing of atrial fibrillation diagnosis nor AF subtype modifies the treatment effect of early versus delayed direct oral anticoagulant initiation in acute ischemic stroke. Pers
The EDESTROKE trial finds no significant difference in 90-day functional outcomes between early (<6h) and delayed (6-12h) extubation post-thrombectomy, shifting focus toward microvascular and hemodynamic optimization.
The BRAVO study provides critical evidence that while IV thrombolysis improves recovery in isolated vertebral artery occlusion, endovascular treatment may increase risks unless reserved for severe cases.
A prospective multicenter study reveals that the no-reflow phenomenon is a dynamic, evolving pathology following successful thrombectomy. It is significantly associated with infarct growth and poor functional outcomes, suggesting that achie
A large-scale multicenter study demonstrates that all subtypes of hemorrhagic transformation, including mild infractions, significantly impair functional recovery after stroke recanalization. Automated noncontrast CT biomarkers now offer su
A five-year prospective study reveals that 13.6% of stroke patients with mild cognitive impairment progress to major VCI, identifying age, diabetes, atrial fibrillation, and small vessel disease as key predictors for long-term cognitive dec
The TRACE-5 trial demonstrates that tenecteplase significantly improves functional outcomes for patients with basilar artery occlusion within 24 hours of onset, offering a safe and effective extension of the therapeutic window for this high
The OPTION trial reveals that tenecteplase administered 4.5 to 24 hours post-stroke in patients with non-large vessel occlusion and salvageable tissue significantly improves functional recovery, although it carries a higher risk of symptoma
Longitudinal data from the Women’s Health Study reveal that elevated Lipoprotein(a) is a potent, independent predictor of myocardial infarction and ischemic stroke over three decades, suggesting a critical need for universal screening in pr
A secondary analysis of the AcT trial demonstrates that high-risk plaque features—such as intraluminal thrombi and carotid webs—significantly increase stroke risk even in patients with less than 50% carotid stenosis, challenging traditional
A comprehensive subgroup analysis of the CATIS and CATIS-2 trials reveals that continuing or reinitiating antihypertensive medication immediately after an acute ischemic stroke does not significantly affect mortality or disability rates, pr
A large-scale study of 144,969 Medicare beneficiaries reveals that initial anticoagulant prescriptions for atrial fibrillation may not reduce ischemic stroke risk in patients over 66, while significantly increasing major bleeding hazards, s
The CERES-TANDEM study provides Class II evidence that emergent carotid stenting (eCAS) during endovascular thrombectomy for tandem lesions significantly improves 90-day functional outcomes without increasing hemorrhagic risk, supporting it
The IsCHEMiA score, an imaging-based risk model validated across international cohorts, offers superior prediction of poststroke epilepsy compared to previous tools. By integrating clinical and neuroimaging markers, it provides a precise fr
The 3-year outcomes of the ATTENTION trial confirm that endovascular thrombectomy for acute basilar artery occlusion provides durable functional benefits and significantly reduces mortality compared to medical management, establishing its l
