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MedXY AI/MedXY News/Tag: Immune Reconstitution
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Optimizing Rabbit ATG Exposure in T-Replete Hematopoietic Cell Transplantation: Insights from BMT CTN 1202
Hematology-OncologyATG exposureBệnh Graft-versus-Host

Optimizing Rabbit ATG Exposure in T-Replete Hematopoietic Cell Transplantation: Insights from BMT CTN 1202

By MedXY|Oct 6, 2026

This analysis of BMT CTN 1202 reveals that rabbit ATG exposure influences survival, relapse, and immune recovery after T-replete hematopoietic cell transplantation, advocating for model-based dosing to optimize outcomes.

Gradual Maturation of the B-Cell Receptor Repertoire After Pediatric Hematopoietic Stem Cell Transplantation: Insights into Early Immune Reconstitution
Hematology-Oncologypediatric HSCT
B-cell receptor repertoire

Gradual Maturation of the B-Cell Receptor Repertoire After Pediatric Hematopoietic Stem Cell Transplantation: Insights into Early Immune Reconstitution

By MedXY|Sep 18, 2026

This study reveals early establishment of a diverse naïve B-cell receptor repertoire within 3 months post-pediatric HSCT, followed by gradual antigen-experienced maturation over 24 months, reflecting physiological B-cell development and sup

Model-Based ATG Dosing Successfully Accelerates CD4+ Reconstitution in CD34+ Selected Allogeneic HCT
Hematology-Oncologyantithymocyte globulinhematopoietic cell transplantation

Model-Based ATG Dosing Successfully Accelerates CD4+ Reconstitution in CD34+ Selected Allogeneic HCT

By MedXY|Jan 13, 2026

A Phase 2 study demonstrates that pharmacokinetic model-based ATG dosing significantly enhances CD4+ T-cell reconstitution in patients undergoing CD34+ selected hematopoietic cell transplantation, reaching primary endpoints in 70% of partic

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