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This large nationwide study demonstrates that coronary CTA-derived FFR-CT strongly predicts future myocardial infarction, cardiovascular death, and revascularization, independent of traditional risk factors and stenosis severity, with a thr
The FUSION randomized trial demonstrates that adding CT-derived FFR to coronary CTA significantly reduces unnecessary invasive angiographies without affecting clinical outcomes, cost, or quality of life in stable CAD patients with intermedi
An 11-year follow-up of the FAME 2 trial reveals that FFR-guided PCI significantly outperforms medical therapy alone in patients with hemodynamically significant stenoses, primarily by reducing urgent revascularizations, with a favorable wi
The NOTION-3 trial demonstrates that FFR-guided revascularization significantly reduces cardiovascular risks in TAVR patients with coronary artery disease, validating the 0.80 threshold for clinical decision-making.
An invasive, placebo‑controlled n‑of‑1 study shows that greater coronary collateral flow is associated with higher ischemic burden but lower pain intensity during controlled coronary occlusion, helping explain the weak correlation between s
The SLIM trial demonstrates that fractional flow reserve–guided complete revascularization during the index procedure significantly reduces major adverse events at one year in patients with NSTEMI and multivessel disease, primarily by lower
The FLAVOUR trial’s extended 6.3-year follow-up shows equivalent long-term outcomes for FFR- and IVUS-guided PCI strategies in intermediate coronary stenosis, with FFR associated with fewer total PCIs but slight increases in late reva
