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Enhancing Diagnostic Accuracy in Stable Coronary Artery Disease: Impact of Adding CT-derived Fractional Flow Reserve (FFRct) – Insights from the FUSION Trial
CardiologyComputed tomographyinvasive coronary angiography

Enhancing Diagnostic Accuracy in Stable Coronary Artery Disease: Impact of Adding CT-derived Fractional Flow Reserve (FFRct) – Insights from the FUSION Trial

By MedXY|Sep 8, 2026

The FUSION randomized trial demonstrates that adding CT-derived FFR to coronary CTA significantly reduces unnecessary invasive angiographies without affecting clinical outcomes, cost, or quality of life in stable CAD patients with intermedi

FFR-Guided PCI Demonstrates Decade-Long Superiority Over Medical Therapy in Stable Coronary Artery Disease
CardiologyFractional Flow ReservePCI
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FFR-Guided PCI Demonstrates Decade-Long Superiority Over Medical Therapy in Stable Coronary Artery Disease

By MedXY|Feb 4, 2026

An 11-year follow-up of the FAME 2 trial reveals that FFR-guided PCI significantly outperforms medical therapy alone in patients with hemodynamically significant stenoses, primarily by reducing urgent revascularizations, with a favorable wi

Validating the 0.80 FFR Threshold: Long-Term Outcomes from the NOTION-3 Trial in TAVR Patients
Cardiologycoronary artery diseaseFractional Flow Reserve

Validating the 0.80 FFR Threshold: Long-Term Outcomes from the NOTION-3 Trial in TAVR Patients

By MedXY|Jan 17, 2026

The NOTION-3 trial demonstrates that FFR-guided revascularization significantly reduces cardiovascular risks in TAVR patients with coronary artery disease, validating the 0.80 threshold for clinical decision-making.

Coronary Collaterals Attenuate Chest Pain in Stable Angina: Evidence From an Invasive Placebo‑Controlled N‑of‑1 Study
CardiologyFractional Flow Reserveischemia

Coronary Collaterals Attenuate Chest Pain in Stable Angina: Evidence From an Invasive Placebo‑Controlled N‑of‑1 Study

By MedXY|Dec 2, 2025

An invasive, placebo‑controlled n‑of‑1 study shows that greater coronary collateral flow is associated with higher ischemic burden but lower pain intensity during controlled coronary occlusion, helping explain the weak correlation between s

FFR-Guided Complete Revascularization Enhances Outcomes in NSTEMI with Multivessel Disease: Insights from the SLIM Trial
CardiologyFractional Flow ReserveMultivessel Disease

FFR-Guided Complete Revascularization Enhances Outcomes in NSTEMI with Multivessel Disease: Insights from the SLIM Trial

By MedXY|Oct 6, 2025

The SLIM trial demonstrates that fractional flow reserve–guided complete revascularization during the index procedure significantly reduces major adverse events at one year in patients with NSTEMI and multivessel disease, primarily by lower

Long-Term Comparative Outcomes of FFR vs IVUS-Guided PCI in Intermediate Coronary Stenosis: Insights from the FLAVOUR Trial Extended Follow-Up
CardiologyFractional Flow ReserveIntravascular Ultrasound

Long-Term Comparative Outcomes of FFR vs IVUS-Guided PCI in Intermediate Coronary Stenosis: Insights from the FLAVOUR Trial Extended Follow-Up

By MedXY|Oct 4, 2025

The FLAVOUR trial’s extended 6.3-year follow-up shows equivalent long-term outcomes for FFR- and IVUS-guided PCI strategies in intermediate coronary stenosis, with FFR associated with fewer total PCIs but slight increases in late reva

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