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Fibroblast-Derived Spondin-2: A Key Driver of Metaplasia-to-Dysplasia Progression in Gastric Epithelium
GastroenterologySpondin-2Dysplasia

Fibroblast-Derived Spondin-2: A Key Driver of Metaplasia-to-Dysplasia Progression in Gastric Epithelium

By MedXY|Aug 28, 2026

This study identifies fibroblast-secreted Spondin-2 as a crucial mediator promoting the transition from metaplastic to dysplastic gastric epithelial cells, advancing understanding of early gastric carcinogenesis.

Stimulating Thyrotropin Receptor Antibodies Amplify Fibroblast Expression of TSH and IGF-1 Receptors: Insights into Thyroid Eye Disease Pathogenesis
Diabetes & Endocrinologyautoantibodies
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fibroblasts

Stimulating Thyrotropin Receptor Antibodies Amplify Fibroblast Expression of TSH and IGF-1 Receptors: Insights into Thyroid Eye Disease Pathogenesis

By MedXY|Jul 1, 2026

Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.

Molecular and Spatial Differences in the Tumor Microenvironment of High-Grade Serous Ovarian Cancer With Short vs Long-Term Survival
newsfibroblastshigh-grade serous ovarian cancer

Molecular and Spatial Differences in the Tumor Microenvironment of High-Grade Serous Ovarian Cancer With Short vs Long-Term Survival

By MedXY|May 26, 2026

This study found that advanced high-grade serous ovarian cancers from short-term survivors had more fibroblasts and stromal invasion signals, while tumors from long-term survivors showed stronger immune pathways, suggesting the tumor microe

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