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This article reviews exploratory analyses from a phase 2b trial examining eosinophil count changes in adults with uncontrolled moderate-to-severe asthma treated with the IL-4Rα inhibitor rademikibart, indicating a low risk of treatment-emer
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
A large retrospective cohort study of 143,517 patients reveals that non-eosinophilic acute exacerbations of COPD carry a significantly higher one-year risk of major adverse cardiovascular events compared with eosinophilic exacerbations, sug