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The APOE ε4 allele significantly reduces survival in Parkinson’s disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.
This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula
This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life
Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.
Extended follow-up from the ASPREE-XT study shows low-dose aspirin does not improve healthy lifespan—defined as survival free of dementia, persistent disability, or death—in healthy older adults, and its risks include increased major hemorr
Metabolic syndrome—characterized by five key metabolic risk factors—significantly increases the risk of dementia, especially vascular dementia, among older adults. Early detection and lifestyle interventions are crucial to protect brain hea
Discover 13 scientifically-supported foods that can help protect and enhance cognitive function, potentially reducing dementia risk as you age.
This 10-year study from England details delirium’s prevalence, associated factors like dementia and frailty, and its lasting impact on mortality and care needs in acute general medicine patients, supporting targeted screening and inte
A culturally adapted, multicomponent caregiver intervention (REACH VN) reduced psychological distress and stress among Vietnamese dementia caregivers at 3 months, though most benefits were not sustained at 6 months, highlighting both promis
Explore ten often-overlooked early signs of dementia, their implications, and evidence-based prevention strategies.
A new meta-analysis finds that the average time from dementia symptom onset to diagnosis is 3.5 years, with even longer delays in younger patients and those with frontotemporal dementia.
Emerging research reveals a compelling connection between common herpes viruses and dementia risk, with vaccination and antiviral treatments showing promise for prevention.
Emerging research reveals a compelling connection between common herpes viruses and dementia risk, with vaccination and antiviral treatments showing promise for prevention.
An in-depth overview of Alzheimer’s disease, covering its causes, symptoms, diagnosis, treatment options, and caregiving strategies.
Recent data reveal that transfeminine adults experience significantly higher prevalence of Alzheimer’s disease and related dementias compared to matched cisgender peers, independent of gender-affirming hormone therapy, highlighting ur
A large-scale emulated trial found no clear overall reduction in dementia risk with GLP-1 receptor agonists versus DPP-4 inhibitors in older adults with type 2 diabetes, though age-specific effects warrant further investigation.
A large phase 3 trial reveals that structured, multidomain lifestyle interventions significantly improve cognition in older adults at risk for cognitive decline, outperforming self-guided strategies.