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Metabolic Signatures and Causal Markers in MRI-Confirmed Lacunar Stroke: Insights from Observational and Mendelian Randomization Analyses
NeurologyMendelian Randomizationcerebral small vessel disease

Metabolic Signatures and Causal Markers in MRI-Confirmed Lacunar Stroke: Insights from Observational and Mendelian Randomization Analyses

By MedXY|Sep 15, 2026

This study identifies glycine and specific lipid cholesterol proportions as metabolomic markers causally linked to lacunar stroke subtypes, enhancing understanding of cerebral small vessel disease pathogenesis and potential biomarkers.

Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities
Neurology
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cerebral small vessel disease
diffusion MRI

Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities

By MedXY|Sep 8, 2026

Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.

DWI-Positive Lesions in Acute Intracerebral Hemorrhage: Insights into Cerebral Small Vessel Disease and Prognosis
Neurologyfunctional outcomeDiffusion-weighted imaging

DWI-Positive Lesions in Acute Intracerebral Hemorrhage: Insights into Cerebral Small Vessel Disease and Prognosis

By MedXY|Aug 15, 2026

DWI-positive lesions in acute intracerebral hemorrhage patients correlate with cerebral small vessel disease markers and predict poorer 6-month outcomes, with lesion distribution varying by small vessel disease subtype.

Impact of Cerebral Small Vessel Disease on Functional Decline: Insights from the Bleeding With Antithrombotic Therapy 2 Study and Related Evidence
CardiologyFunctional DeclineLiệu pháp chống huyết khối

Impact of Cerebral Small Vessel Disease on Functional Decline: Insights from the Bleeding With Antithrombotic Therapy 2 Study and Related Evidence

By MedXY|Jul 3, 2026

Cerebral small vessel disease (SVD) significantly contributes to functional decline independently of bleeding or ischemic events during antithrombotic therapy, underscoring the need for targeted management strategies to address SVD burden i

Incidental DWI-Positive Lesions as Emerging Biomarkers in Cerebral Small Vessel Disease: Insights from CAA and CADASIL Cohorts
NeurologyCAACADASIL

Incidental DWI-Positive Lesions as Emerging Biomarkers in Cerebral Small Vessel Disease: Insights from CAA and CADASIL Cohorts

By MedXY|Jun 28, 2026

Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as m

Wider Intracranial Arteries, Not Cranial Arterial Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease
NeurologydolichoectasiaIntracranial Stenosis

Wider Intracranial Arteries, Not Cranial Arterial Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease

By MedXY|Jun 10, 2026

In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and w

Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk
Neurologycognitive declineDementia

Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk

By MedXY|May 13, 2026

In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.

Wider Cranial Arteries, Not Atherosclerotic Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease
Neurologydolichoectasiaintracranial arterial stenosis

Wider Cranial Arteries, Not Atherosclerotic Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease

By MedXY|May 6, 2026

In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.

Biological Age Outpaces Chronological Age in Predicting Cerebral Small Vessel Disease Progression
Cardiologybiological agingcognitive decline

Biological Age Outpaces Chronological Age in Predicting Cerebral Small Vessel Disease Progression

By MedXY|Apr 14, 2026

This longitudinal cohort study reveals that biomarker-based biological age, particularly KDMAge and PhenoAge residuals, significantly predicts progression of cerebral small vessel disease, including new lacunes and microbleeds, offering pot

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