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biomarkers

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Cellular Adhesion Molecules as Prognostic Biomarkers and Therapeutic Insights in Chronic Heart Failure: Integrative Review Emphasizing DAPA-HF Findings

Cellular Adhesion Molecules as Prognostic Biomarkers and Therapeutic Insights in Chronic Heart Failure: Integrative Review Emphasizing DAPA-HF Findings

Elevated VCAM-1 levels correlate with worse outcomes in chronic HFrEF, independent of conventional markers; dapagliflozin’s benefits are consistent across VCAM-1 levels, highlighting inflammatory pathways as therapeutic targets.

Section: CardiologyDec 4, 2025

Extratemporal epilepsy, obesity and male sex predict SUDEP risk in drug‑resistant focal epilepsy: clinical insights from the REPO2MSE prospective case‑control study

Extratemporal epilepsy, obesity and male sex predict SUDEP risk in drug‑resistant focal epilepsy: clinical insights from the REPO2MSE prospective case‑control study

A multicentre prospective nested case‑control analysis (REPO2MSE) identifies extratemporal seizure onset, BMI ≥30, male sex, and predominantly nocturnal seizures as independent SUDEP risk factors in drug‑resistant focal epilepsy; peri‑ictal

Section: NeurologyDec 2, 2025

High-Sensitivity Cardiac Troponins and Dementia Risk: Insights from Longitudinal Cohort Studies

High-Sensitivity Cardiac Troponins and Dementia Risk: Insights from Longitudinal Cohort Studies

Elevated high-sensitivity cardiac troponin I and T levels, indicative of subclinical myocardial injury in midlife, are associated with accelerated cognitive decline, structural brain changes, and increased dementia risk in later life.

Section: CardiologyNov 28, 2025

Biomarker-Guided Preventive Care Halves Risk of Moderate–Severe AKI After Major Surgery: Results from BigpAK-2

Biomarker-Guided Preventive Care Halves Risk of Moderate–Severe AKI After Major Surgery: Results from BigpAK-2

In BigpAK-2, a multinational randomized trial, a KDIGO-based preventive bundle triggered by tubular stress biomarkers reduced moderate or severe acute kidney injury within 72 hours after major surgery (OR 0.57; NNT 12) without increasing ad

Section: Critical CareNov 26, 2025

Lacosamide Lowers Peripheral Nerve Excitability in Large Myelinated Fibers: Randomized Crossover Evidence and Biomarker Implications

Lacosamide Lowers Peripheral Nerve Excitability in Large Myelinated Fibers: Randomized Crossover Evidence and Biomarker Implications

A randomized, double‑blind crossover trial in healthy volunteers found lacosamide acutely reduced strength–duration time constant and other excitability metrics in large myelinated peripheral fibers; pregabalin and tapentadol produced no co

Section: AnesthesiologyNov 6, 2025

Obesity Alters Symptom Trajectory and Inflammatory Signatures after Sport-Related Concussion: the NCAA‑DoD CARE Consortium

Obesity Alters Symptom Trajectory and Inflammatory Signatures after Sport-Related Concussion: the NCAA‑DoD CARE Consortium

In a large prospective cohort, obese BMI (≥30) was associated with worse post-concussion neurocognitive outcomes and a persistently proinflammatory blood biomarker profile, despite fewer baseline symptoms. Findings suggest obesity modifies

Section: Diabetes & EndocrinologyNov 5, 2025

Reduced Threat-Related Neural Efficiency as a Biomarker for Pediatric Anxiety: Implications for Diagnosis and CBT Response

Reduced Threat-Related Neural Efficiency as a Biomarker for Pediatric Anxiety: Implications for Diagnosis and CBT Response

This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target

Section: newsOct 30, 2025

Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers

Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers

This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.

Section: Allergy & ImmunologyOct 24, 2025

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Section: Internal MedicineOct 21, 2025

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains u

Section: Internal MedicineOct 20, 2025

Enlarged Perivascular Spaces as Early Neurovascular Biomarkers in Alzheimer Disease: Integrating Serum and MRI Findings from Multicultural Cohorts

Enlarged Perivascular Spaces as Early Neurovascular Biomarkers in Alzheimer Disease: Integrating Serum and MRI Findings from Multicultural Cohorts

Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contribut

Section: Clinical UpdatesOct 20, 2025

Decoding Response-Adapted Daratumumab Therapy in Elderly Multiple Myeloma: Biomarkers and Mechanisms of Sensitivity and Resistance

Decoding Response-Adapted Daratumumab Therapy in Elderly Multiple Myeloma: Biomarkers and Mechanisms of Sensitivity and Resistance

A response-adapted trial of daratumumab monotherapy in elderly newly diagnosed multiple myeloma reveals key biomarkers—CD38 expression, plasma cell phenotype, and immune microenvironment—that predict treatment sensitivity and inform therape

Section: Hematology-OncologyOct 15, 2025

Alzheimer’s Disease: Navigating Controversies and Shaping Future Strategies

Alzheimer’s Disease: Navigating Controversies and Shaping Future Strategies

Recent advances in anti-β amyloid monoclonal antibodies offer promising reductions in Alzheimer’s disease progression but spark debate regarding their clinical impact, cost-effectiveness, and accessibility. Emerging biomarkers and preventiv

Section: NeurologyOct 11, 2025

Noninvasive Biomarkers Track Semaglutide Efficacy in Metabolic Dysfunction-Associated Steatohepatitis

Noninvasive Biomarkers Track Semaglutide Efficacy in Metabolic Dysfunction-Associated Steatohepatitis

A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.

Section: Diabetes & EndocrinologyOct 9, 2025

Biomarker-Guided ABC-AF Risk Scores in Atrial Fibrillation: Insights from a Large Multicenter Randomized Trial

Biomarker-Guided ABC-AF Risk Scores in Atrial Fibrillation: Insights from a Large Multicenter Randomized Trial

A biomarker-based ABC-AF risk score-guided treatment did not improve stroke or death outcomes versus standard care in atrial fibrillation, underscoring the need for prospective validation of precision medicine tools before clinical implemen

Section: CardiologyOct 7, 2025

Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment

Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment

Mental disorders currently diagnosed symptomatically can be redefined using biology-informed frameworks integrating biological, behavioral, and environmental data. The Precision Psychiatry Roadmap aims to harmonize global research and clini

Section: Clinical UpdatesOct 6, 2025

Decoding Fractional Exhaled Nitric Oxide (FeNO) Across the Lifespan: Establishing Normal Ranges in a Respiratory Healthy Population

Decoding Fractional Exhaled Nitric Oxide (FeNO) Across the Lifespan: Establishing Normal Ranges in a Respiratory Healthy Population

This study establishes reliable FeNO reference values throughout life in respiratory healthy individuals, highlighting factors that influence nitric oxide levels and enhancing asthma diagnosis and management.

Section: RespiratoryOct 6, 2025

Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome

Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome

A comprehensive proteomic analysis from the ARIC study identifies plasma proteins linking kidney dysfunction to incident heart failure, highlighting potential biomarkers and therapeutic targets for HF prevention in CKD patients.

Section: CardiologyOct 4, 2025

Vutrisiran’s Impact on Cardiac Function and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from HELIOS-B

Vutrisiran’s Impact on Cardiac Function and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from HELIOS-B

Vutrisiran improves cardiac structure, function, and biomarkers, reducing mortality and cardiovascular events in transthyretin amyloid cardiomyopathy over 30 months.

Section: CardiologyOct 4, 2025

Predicting Long-Term Mortality: Insights from a Multi-Metabolite Signature in the PREDIMED Trial

Predicting Long-Term Mortality: Insights from a Multi-Metabolite Signature in the PREDIMED Trial

A study identified a robust plasma multi-metabolite signature that predicts long-term all-cause mortality in participants from the PREDIMED trial and several US cohorts, providing new insights into metabolic biomarkers.

Section: Diabetes & EndocrinologyOct 3, 2025

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