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MedXY News - atherosclerosis

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atherosclerosis

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GLP-1 Receptor Agonists: A Breakthrough in Reducing Atherosclerosis and Cardiovascular Risk Beyond Diabetes and Obesity

GLP-1 Receptor Agonists: A Breakthrough in Reducing Atherosclerosis and Cardiovascular Risk Beyond Diabetes and Obesity

GLP-1 receptor agonists significantly reduce atherosclerosis progression, inflammatory biomarkers, and cardiovascular events independent of glycaemic control and obesity status, evidenced by robust preclinical and large-scale clinical data.

Section: CardiologyJul 22, 2026

Non-HDL Cholesterol and Apolipoprotein B Measures and Risk of Atherosclerotic Cardiovascular Disease

Non-HDL Cholesterol and Apolipoprotein B Measures and Risk of Atherosclerotic Cardiovascular Disease

This study compares the predictive value of non-HDL cholesterol and apolipoprotein B for atherosclerotic cardiovascular disease risk in individuals not on lipid-lowering medication.

Section: CardiologyJul 16, 2026

Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure

Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure

In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.

Section: CardiologyJun 20, 2026

Silent Plaque Ruptures in Non-Obstructive Lesions of Non-Infarct-Related Arteries: What Serial Coronary Imaging Reveals

Silent Plaque Ruptures in Non-Obstructive Lesions of Non-Infarct-Related Arteries: What Serial Coronary Imaging Reveals

In patients with acute myocardial infarction, silent plaque rupture was found in 12% of non-obstructive lesions in non-infarct-related arteries. Larger plaques, positive remodeling, and thinner fibrous caps were linked to rupture, and more

Section: CardiologyJun 11, 2026

Apolipoprotein C-III Inhibition and the Atherosclerosis Paradox: Lessons from the Essence-TIMI 73b Olezarsen Study

Apolipoprotein C-III Inhibition and the Atherosclerosis Paradox: Lessons from the Essence-TIMI 73b Olezarsen Study

The Essence-TIMI 73b trial reveals that despite a 64% reduction in triglycerides and a 72% drop in remnant cholesterol via olezarsen, non-calcified coronary plaque volume remained unchanged over 12 months.

Section: CardiologyApr 10, 2026

Inhibiting Myeloid-PlexinD1: A Novel Strategy to Stabilize Atherosclerosis at High-Risk Vascular Bifurcations

Inhibiting Myeloid-PlexinD1: A Novel Strategy to Stabilize Atherosclerosis at High-Risk Vascular Bifurcations

Research reveals that PlexinD1 mediates macrophage-driven inflammation in response to disturbed blood flow. By targeting this pathway, scientists have successfully attenuated plaque progression in preclinical models, paving the way for adva

Section: CardiologyMar 9, 2026

ACTA2 Pathogenic Variants: Unmasking the Link Between Smooth Muscle Cell Stress and Early-Onset Atherosclerosis

ACTA2 Pathogenic Variants: Unmasking the Link Between Smooth Muscle Cell Stress and Early-Onset Atherosclerosis

Recent research identifies a specific molecular pathway—driven by HSF1 activation and increased cholesterol biosynthesis in smooth muscle cells—that explains why certain ACTA2 mutations predispose patients to premature atherosclerotic cardi

Section: CardiologyMar 4, 2026

Angiographic Burden of Coronary Atherosclerosis: The Critical Mediator Between ASCVD Risk Factors and Cardiovascular Outcomes

Angiographic Burden of Coronary Atherosclerosis: The Critical Mediator Between ASCVD Risk Factors and Cardiovascular Outcomes

This Mendelian randomization study reveals that coronary plaque burden significantly mediates the link between traditional risk factors and adverse events like myocardial infarction and heart failure, reinforcing the necessity of early prim

Section: CardiologyMar 2, 2026

Distinct Neuroimaging Signatures: Atrial Fibrillation and Atherosclerosis Drive Divergent Vascular Brain Lesion Patterns

Distinct Neuroimaging Signatures: Atrial Fibrillation and Atherosclerosis Drive Divergent Vascular Brain Lesion Patterns

A large-scale comparative study of 3,508 patients reveals that atrial fibrillation and atherosclerosis produce significantly different vascular brain lesions on MRI, with AF favoring non-lacunar infarcts and periventricular white matter cha

Section: CardiologyJan 6, 2026

Elevated LDL-C Increases Cardiovascular Risk in Symptomatic Patients Despite a Coronary Calcium Score of Zero

Elevated LDL-C Increases Cardiovascular Risk in Symptomatic Patients Despite a Coronary Calcium Score of Zero

A large-scale cohort study from the Western Denmark Heart Registry demonstrates that high LDL-C remains a significant predictor of non-calcified plaque and coronary heart disease events in patients with a CAC score of zero, particularly amo

Section: CardiologyJan 4, 2026

Long-Term Silicon Exposure Fails to Predict Coronary Artery Disease Severity or Systemic Inflammation

Long-Term Silicon Exposure Fails to Predict Coronary Artery Disease Severity or Systemic Inflammation

A pilot study evaluating hair silicon as a long-term mineral marker found no significant association between silicon concentrations and coronary artery disease (CAD) severity or inflammatory markers, suggesting silicon may be metabolically

Section: CardiologyDec 24, 2025

Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention

Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention

A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%) co

Section: CardiologyDec 3, 2025

Invisible Invaders: How Microplastics May Accelerate Atherosclerosis — and Why Men Could Be at Greater Risk

Invisible Invaders: How Microplastics May Accelerate Atherosclerosis — and Why Men Could Be at Greater Risk

New animal research links oral microplastic exposure to dramatic increases in arterial plaque—especially in males—by injuring endothelial cells and provoking inflammation and oxidative stress.

Section: CardiologyNov 25, 2025

Targeting NEK7 with an Oral Molecular-Glue Degrader: MRT-8102 Advances an Upstream Inflammasome Strategy for Cardiovascular Inflammation

Targeting NEK7 with an Oral Molecular-Glue Degrader: MRT-8102 Advances an Upstream Inflammasome Strategy for Cardiovascular Inflammation

Preclinical AHA 2025 data show MRT-8102, an oral NEK7-directed molecular glue degrader, selectively degrades NEK7, suppresses NLRP3 inflammasome activation and pyroptosis across species, and reduces multi-cytokine release—supporting Phase 1

Section: CardiologyNov 12, 2025

Subclinical Vascular Burden Predicts 20‑Year Cognitive Decline: Arteriosclerosis and Atherosclerosis Outperform Blood Pressure and Cardiac Measures

Subclinical Vascular Burden Predicts 20‑Year Cognitive Decline: Arteriosclerosis and Atherosclerosis Outperform Blood Pressure and Cardiac Measures

In MESA, baseline subclinical arteriosclerosis and atherosclerosis scores predicted greater cognitive decline and higher odds of MCI/dementia over 20 years, independently of clinical dementia risk factors.

Section: CardiologyNov 5, 2025

The Hidden Cardiovascular Risks of Anabolic Steroid Abuse in Men and Women: Insights from a Danish Study

The Hidden Cardiovascular Risks of Anabolic Steroid Abuse in Men and Women: Insights from a Danish Study

This study highlights the association between illicit anabolic steroid use and adverse cardiovascular outcomes in both sexes, emphasizing the need for preventive strategies in recreational sports.

Section: CardiologyOct 28, 2025

Repurposing Antihypertensive Drug Trazosin to Delay Vascular Aging: A Breakthrough in Atherosclerosis Management

Repurposing Antihypertensive Drug Trazosin to Delay Vascular Aging: A Breakthrough in Atherosclerosis Management

New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis pr

Section: CardiologyOct 8, 2025

The Hidden Vascular Assassin: How Homocysteine Independently Accelerates Atherosclerosis

The Hidden Vascular Assassin: How Homocysteine Independently Accelerates Atherosclerosis

Beyond cholesterol and blood pressure, homocysteine silently hardens arteries, driving cardiovascular disease progression independently—latest research reveals its biomechanical impact and prevention strategies.

Section: Medical NewsSep 14, 2025

The Hidden Threat in Your Mouth: How Oral Bacteria Can Trigger Heart Attacks

The Hidden Threat in Your Mouth: How Oral Bacteria Can Trigger Heart Attacks

New research reveals that common oral bacteria, particularly Viridans streptococci, can infiltrate arterial plaques, increasing the risk of heart attacks by triggering inflammation and plaque rupture.

Section: DentistryOct 24, 2025

Lipoprotein(a) as a Prognostic Indicator for Extracoronary Atherosclerotic Disease Progression: Insights from the UK Biobank

Lipoprotein(a) as a Prognostic Indicator for Extracoronary Atherosclerotic Disease Progression: Insights from the UK Biobank

Elevated lipoprotein(a) levels significantly predict incident peripheral artery disease and carotid stenosis, as well as progression to major limb events, underscoring its value as a prognostic biomarker for extracoronary atherosclerotic va

Section: CardiologyOct 7, 2025