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Evaluating Vericiguat in Coronary Vasospasm: Insights from the ViVA Randomized Cross-Over Trial
CardiologyvericiguatCoronary Vasospasm

Evaluating Vericiguat in Coronary Vasospasm: Insights from the ViVA Randomized Cross-Over Trial

By MedXY|Sep 8, 2026

This article reviews the ViVA trial assessing vericiguat, an sGC stimulator, in angina patients with coronary vasospasm but no obstructive coronary artery disease. The study found no significant improvement in vasodilator function or angina

More ANOCA Endotypes, More Angina: Comprehensive Coronary Function Testing Reveals a Graded Symptom Burden
Cardiologyangina burdenANOCA
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More ANOCA Endotypes, More Angina: Comprehensive Coronary Function Testing Reveals a Graded Symptom Burden

By MedXY|Jun 9, 2026

In patients with ANOCA, overlapping coronary endotypes were common, and each additional abnormality identified on comprehensive coronary function testing was associated with significantly worse angina burden.

Routine Coronary Function Testing in ANOCA Improves Symptoms: Key Results from the ILIAS ANOCA Trial
CardiologyanginaANOCA

Routine Coronary Function Testing in ANOCA Improves Symptoms: Key Results from the ILIAS ANOCA Trial

By MedXY|Nov 28, 2025

The ILIAS ANOCA randomized trial shows that routine invasive coronary function testing (CFT) during angiography in patients with angina and non‑obstructive coronary arteries (ANOCA) is feasible, safe, yields a high diagnostic rate of vasomo

Mechanism-led Classification of ANOCA: Eight Distinct Endotypes Enable Targeted Treatment
CardiologyANOCA

Mechanism-led Classification of ANOCA: Eight Distinct Endotypes Enable Targeted Treatment

By MedXY|Nov 28, 2025

A 1,001‑patient multicentre study identifies eight haemodynamic endotypes in angina with non‑obstructive coronary arteries (ANOCA) using adenosine and acetylcholine testing, supporting mechanism-guided, endotype-specific therapy and stratif

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