Alzheimer's disease

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Plasma p-tau217 and GFAP Emerge as Robust Predictors of Alzheimer’s Progression in Down Syndrome

A pivotal longitudinal study demonstrates that plasma p-tau217 and GFAP accurately predict amyloid-β and tau deposition, cognitive decline, and dementia risk in adults with Down syndrome, offering a transformative, non-invasive tool for cli

Section: NeurologyDec 23, 2025

Stage-specific Tau-PET Dynamics in Biological Alzheimer’s Disease: Implications for Trial Design and Outcome Selection

Longitudinal tau-PET accumulation follows distinct regional patterns across biological AD stages; aligning trial inclusion and outcome ROIs to baseline tau stage can substantially reduce sample sizes and improve power for disease-modifying

Alzheimer's disease

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Plasma p-tau217 and GFAP Emerge as Robust Predictors of Alzheimer’s Progression in Down Syndrome

Stage-specific Tau-PET Dynamics in Biological Alzheimer’s Disease: Implications for Trial Design and Outcome Selection

Connectivity as a Universal Predictor of Tau Progression in Atypical Alzheimer’s Disease: A Multicentre Evidence Synthesis

Low‑Dose Interleukin‑2 Expands Regulatory T Cells and Modulates Biomarkers in Mild–Moderate Alzheimer’s Disease: Phase 2a Randomized Trial Shows Safety and Promising Signals

Lipoprotein(a) and Dementia: Large Cohorts Show No Clear Link — But Small Apo(a) Isoforms May Raise Alzheimer’s Risk

Aducanumab Removes Superficial Cortical Amyloid but Associates with Local Vascular Injury and ARIA: Clinicopathological Evidence from a Retrospective Case–Control Study

Amyloid PET Centiloid Predicts Lifetime and 10‑Year Risk of MCI and Dementia in Cognitively Unimpaired Adults

Tracking Steps to Slow Alzheimer’s: Physical Activity Linked to Reduced Tau Accumulation and Slower Decline in Preclinical AD

Two-Year 40 Hz Audiovisual Stimulation in Mild Alzheimer’s: Safety, EEG Entrainment, and Early Biomarker Signals

Contactless In-Home Longitudinal Monitoring of Night-Time Sleep Patterns and Physiology in Aging and Alzheimer’s Disease

Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease

New International Research Recommendations on Sleep and Circadian Measures in Aging and Alzheimer’s Disease

Depression, Anxiety and PTSD Associated With Earlier Onset of Alzheimer’s Disease: Psychiatric Burden Lowers Age at Symptom Onset

Unlocking the Predictive Power of Plasma Biomarkers for Early Alzheimer’s Disease Detection

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications

Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study

Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women

Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More

Rapamycin for Alzheimer’s Prevention in APOE4 Carriers: Restoring Brain Metabolism and Vascular Health