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Decoding ATRA Resistance in Acute Promyelocytic Leukemia: The Role of PML::RARA Mutations Enhancing Basal Repression
Hematology-Oncologytranscriptional repressionAcute Promyelocytic Leukemia

Decoding ATRA Resistance in Acute Promyelocytic Leukemia: The Role of PML::RARA Mutations Enhancing Basal Repression

By MedXY|Aug 24, 2026

A clustered subset of hotspot PML::RARA mutations drives ATRA resistance in acute promyelocytic leukemia by enhancing basal transcriptional repression rather than disrupting transactivation, suggesting novel mechanisms underlying therapeuti

APOLLO Trial Highlights Superior Efficacy of Arsenic Trioxide Plus ATRA in High-Risk Acute Promyelocytic Leukemia
Hematology-OncologyAcute Promyelocytic Leukemia

APOLLO Trial Highlights Superior Efficacy of Arsenic Trioxide Plus ATRA in High-Risk Acute Promyelocytic Leukemia

By MedXY|Oct 7, 2025

The phase III APOLLO trial demonstrates that arsenic trioxide combined with all-trans retinoic acid (ATRA) plus low-dose idarubicin improves event-free survival and reduces relapse rates compared to standard ATRA plus anthracycline chemothe

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