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In acute ischemic stroke patients with excellent reperfusion, elevated peri-infarct microvascular heterogeneity measured by MRI predicts infarct growth and poor functional recovery, reflecting the no-reflow phenomenon despite restored macro
This study evaluates differential item functioning in the EQ-5D-5L questionnaire among acute ischemic stroke patients, revealing minimal impact of age-related biases on quality of life measurement across sex and treatment groups.
This study evaluates the eligibility of children with acute ischemic stroke (AIS) for thrombolysis with tPA, revealing only 19% potential eligibility under current guidelines, and highlights opportunities to reconsider treatment in small-ve
The ENCHANTED trial post hoc analysis reveals body weight does not alter alteplase dose effectiveness in acute ischemic stroke, but low body weight independently predicts poorer outcomes without increased hemorrhagic risk.
A post hoc analysis of the BRIDGE-TNK trial reveals that intravenous tenecteplase before endovascular thrombectomy significantly improves functional independence in acute large-vessel occlusion stroke patients with extensive baseline ischem
This study presents a deep learning model that generates synthetic T-max perfusion maps from noncontrast DWI and FLAIR sequences, potentially streamlining stroke imaging and eliminating the need for contrast agents.
A phase IIb trial shows that adding normobaric hyperoxia to endovascular thrombectomy in acute ischemic stroke patients 6 to 24 hours after onset is safe, improves early neurological outcomes, and reduces infarct volume, warranting larger c
A randomized trial shows reperfusion-guided blood pressure management post-thrombectomy improves functional outcomes and reduces hemorrhagic transformation, supporting personalized BP targets based on reperfusion status.
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
In a 3919-patient individual-level meta-analysis, acute cardiac CT detected cardiac thrombi in 6.2% of ischemic stroke cases, exceeded transthoracic echocardiography yield, added modest imaging burden, and identified patients with worse 90-
In a randomized trial of large-vessel-occlusion stroke, standard-dose tenecteplase improved early reperfusion before thrombectomy compared with low-dose alteplase, with similar safety and functional outcomes.
In patients with large-vessel-occlusion stroke undergoing thrombectomy, standard-dose tenecteplase achieved more early reperfusion than low-dose alteplase, with similar safety and functional outcomes.
Real-world registry data suggest that reversing dabigatran with idarucizumab before IV thrombolysis in acute ischemic stroke is safe and yields outcomes similar to patients not on oral anticoagulants.
This review synthesizes recent evidence comparing ‘mothership’ and ‘drip-and-ship’ strategies in acute ischemic stroke, highlighting functional benefits of direct transport and the critical 43-minute delay threshold.
A retrospective study of 489,360 patients reveals that right-sided middle cerebral artery strokes are associated with significantly higher inpatient mortality and complications compared to left-sided strokes, likely due to inherent scoring
Recent multi-site randomized evidence demonstrates that adding intravenous argatroban or eptifibatide to standard thrombolysis within 3 hours of stroke onset does not improve functional recovery and is associated with increased mortality, i
In patients with anterior large‑vessel stroke who achieved successful reperfusion, lower penumbral oxygen extraction fraction (OEFr) on baseline DSC‑MRI independently predicted substantial infarct growth and greater penumbra-to-infarct conv
Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.
The RESCUE trial demonstrates that RNS60, a novel oxygen-supersaturated saline solution, is safe and reduces infarct growth when added to endovascular thrombectomy in acute ischemic stroke due to large vessel occlusion, supporting further i
The HOPE trial demonstrates that intravenous alteplase administered 4.5 to 24 hours after ischemic stroke onset improves functional independence in patients with salvageable brain tissue, despite increased risk of symptomatic intracranial h
