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Skin Denervation as a Biomarker Linked to Cognitive Decline and Brain Atrophy in Parkinson Disease

MedXY Editorial Team•Oct 5, 2026•Neurology
Brain Atrophycognitive impairmentParkinson diseasesmall fiber neuropathy

Highlight

– Progressive reduction in intraepidermal nerve fiber density (IENFD) parallels worsening cognitive impairment in Parkinson disease (PD).
– Lower IENFD correlates with frontal and insular gray matter atrophy, regions linked to cognitive functions.
– Skin denervation independently predicts cognitive impairment severity and distinguishes PD cognitive subtypes with good diagnostic accuracy.
– Brain atrophy statistically mediates the relationship between peripheral small fiber loss and cognitive deficits, supporting a peripheral-central neurodegenerative axis in PD.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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