Progress and Prognostic Insights in Fetal Cardiomyopathy: Findings from a Multicenter North American Cohort

Highlight

– Contemporary fetal cardiomyopathy shows improved survival but remains associated with significant mortality and transplant risk in infancy.
– Genetic testing identifies causal variants in approximately one-third of cases, informing diagnosis and potential management.
– Fetal hydrops and prenatal diagnosis of extracardiac structural anomalies predict poorer outcomes by one year of age.
– Cardiac transplantation remains a critical therapeutic option for a subset of affected neonates.

Study Background