Access to Patient-Reported Outcome (PRO) data significantly improved inter-rater reliability (ICC) for 13 of 17 symptomatic adverse events in a multinational RCT.
The most substantial improvements in assessment consistency occurred for subjective symptoms such as memory impairment, irritability, and concentration.
The study supports the systematic integration of PROs into oncology clinical trials to mitigate provider under-reporting and improve the accuracy of safety data.
While most symptoms showed improved reliability, some objective symptoms like diarrhea showed unexpected results, suggesting the need for nuanced interpretation of multi-source data.
The Limitations of Provider-Only Toxicity Grading
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
