Novel Peripheral Retinal Vascular Biomarker on Ultra-Widefield OCTA Enables Severity Grading in Retinitis Pigmentosa

Highlight

• Identification of two distinct peripheral retinal vascular phenotypes in retinitis pigmentosa (RP) via ultra-widefield OCT angiography (UWF-OCTA): Terminal Remodeling and Simple Atrophy.
• Validation of the chorioretinal neovascular zone (CNZ) area as a robust quantitative biomarker correlating strongly with multiple visual function measures.
• Development and validation of a clinically applicable four-stage severity grading system based on CNZ area reliably stratifying RP disease progression.
• Potential for the grading system to enhance disease monitoring and patient stratification in future interventional trials.

Study Background