Negative Pressure Therapy in Major Lower Extremity Amputation: A Critical Review of Current Randomized Controlled Trials
Highlights
- Major lower extremity amputation patients face high rates of postoperative wound complications, a significant clinical burden.
- Negative pressure therapy (NPT) has demonstrated efficacy in reducing surgical site infections (SSI) and accelerating rehabilitation in select trials, though overall benefit remains inconsistent.
- Large randomized controlled trials reveal no significant overall reduction in wound complications with NPT versus standard dressing but suggest possible advantages in high-risk subgroups such as non-diabetics, patients with ESRD, obesity, or without tissue loss.
- Further large, well-powered trials focusing on specific patient cohorts and incorporating longer follow-up and patient-centered outcomes are needed to delineate the role of NPT in this population.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.