Left Atrial Dysfunction and Vutrisiran Efficacy in Transthyretin Amyloid Cardiomyopathy: Insights from the HELIOS-B Trial
Highlight
- Left atrial (LA) dysfunction, notably impaired LA strain, is prevalent in transthyretin amyloidosis with cardiomyopathy (ATTR-CM) and independently predicts adverse outcomes including mortality, heart failure hospitalizations, and atrial fibrillation.
- LA volume index (LAVi), a traditional measure of atrial remodeling, was not predictive of clinical events in this population, highlighting the superior prognostic value of strain-based functional assessment.
- Vutrisiran, an RNA silencing therapy targeting transthyretin, mitigated progressive LA functional decline over 30 months, suggesting a beneficial impact on atrial myopathy beyond its known effects on ventricular parameters.
- LA strain did not modify the treatment effect of vutrisiran, supporting its consistent benefits across varying degrees of atrial dysfunction in ATTR-CM.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.