Hospitalization Burden and Outcomes in Congenital Adrenal Hyperplasia Across the Lifespan: Insights from a Swiss Population-Based Cohort Study

Highlight

This large Swiss cohort study encompassing over 12 million hospitalizations elucidates significant hospitalization patterns and outcomes for patients with Congenital Adrenal Hyperplasia (CAH) across different life stages. Key highlights include: (1) The highest hospitalization incidence in CAH occurs during neonatal and early childhood periods; (2) Endocrine and metabolic disorders represent the predominant reasons for admission at all ages in CAH patients; (3) Patients with CAH demonstrate a substantially increased burden of comorbidities and higher rates of severe in-hospital complications, especially intensive care unit (ICU) admissions in infancy; (4) These findings underscore the critical importance of timely recognition and tailored management strategies for CAH across the lifespan.

Study Background