Highlight
– The eVENT multicentre randomised trial evaluated the impact of a national French telemonitoring programme on home NIV effectiveness during follow-up.
– Telemonitoring with remote support did not significantly improve nocturnal transcutaneous CO2 but significantly lowered arterial CO2 levels and reduced hypercapnia.
– Telemonitoring was associated with better NIV adherence, more days with usage ≥4 hours, and fewer non-intentional leaks.
– Findings support integrating real-world telemonitoring programmes with therapeutic education to optimize home NIV outcomes.