Histidine-Rich Glycoprotein as a Modulator of Platelet Adhesion and Aggregation: Mechanistic Insights and Clinical Implications
Highlights
- HRG binds directly to platelet membrane receptors GPIbα and GPIIb/IIIa, modulating platelet function.
- It competes with von Willebrand factor (VWF) and fibrinogen for receptor binding, impairing platelet adhesion and aggregation.
- HRG attenuates platelet-mediated thrombus formation under high-shear conditions in vitro.
- Pathological reductions of plasma HRG levels in sepsis and COVID-19 associate with a hyperreactive platelet phenotype, implicating HRG in thromboinflammatory disease modulation.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.