Frontline Allogeneic Transplantation Outperforms Pretransplant IPSS-M Downstaging in Myelodysplastic Neoplasms
Highlights
In this retrospective single-center analysis of 128 adults with myelodysplastic neoplasms undergoing allogeneic hematopoietic cell transplantation, pretransplant therapy did not translate into better post-transplant outcomes.
Although IPSS-M improved before transplantation in a subset of patients, molecular or composite-risk “downstaging” was modest and showed no clear survival advantage.
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