Fludarabine with Treosulfan vs. Total Body Irradiation as Conditioning in ALL Transplantation: A Comparative Retrospective Analysis
Acute Lymphoblastic Leukemiaallogeneic stem cell transplantationconditioning regimentotal body irradiationtreosulfan
Highlight
- Fludarabine combined with treosulfan (FluTreo) and fludarabine with total body irradiation (FluTBI) were compared as conditioning regimens before allogeneic HSCT in adult acute lymphoblastic leukemia (ALL).
- No significant differences were found in the incidences of acute/chronic graft-versus-host disease (GVHD), relapse, or non-relapse mortality between the two groups.
- Leukemia-free survival and overall survival rates showed a nonsignificant trend favoring FluTBI, but outcomes were generally comparable.
- This study supports FluTreo as a valid conditioning alternative for patients in complete remission prior to alloHSCT in ALL.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.