Early Retinal Sensitivity Decline in Intermediate AMD: Insights from Lesion-Centered Functional Trajectories in the PINNACLE Study

Highlight

The prospective PINNACLE study reveals early and distinct patterns of retinal sensitivity loss in intermediate age-related macular degeneration (iAMD) localized to specific lesion types. Sensitivity decline precedes structural detection at ellipsoid zone/interdigitation zone loss sites, exhibits central retinal spatial vulnerability, and varies by lesion subtype. These findings support lesion-specific functional monitoring using microperimetry despite notable measurement variability.

Study Background