Distinct Gut Microbiome Signatures Predict Short-term Hospitalisation Risk in Cirrhosis: Insights from a Global Metagenomic Study

Highlight

• Gut microbiome diversity loss and specific bacterial species alterations associate with 90-day hospitalisation in cirrhosis across multinational cohorts.
• Functional metagenomic shifts emphasize changes in carbohydrate metabolism and antimicrobial resistance pathways in hospitalised cirrhosis patients.
• Integrated clinical and microbiome-based prediction models significantly improve hospitalisation risk stratification beyond clinical parameters alone.

Study Background