Decoding Bone Marrow Architecture: A New Biomarker for Disease Activity and Treatment Response in Myelodysplastic Neoplasms

MedXY Editorial Team•Aug 17, 2026•Hematology-Oncology

Myelodysplastic neoplasms (MDS) provoke profound spatial alterations in bone marrow microarchitecture beyond blast count abnormalities.
Multiplex immunofluorescence combined with single-cell phenotyping enables quantification of >5 million spatially resolved marrow cells in patients and controls.
A novel Microarchitectural Perturbation Score (MDS-MAPS) summarizes 82 architectural features, outperforming blast percentage in distinguishing active disease from remission and low-blast MDS from clonal cytopenia of undetermined significance.
MDS-MAPS dynamically tracks marrow remodeling during treatment, correlating with disease activity independently of blast burden and indicating tissue-state normalization or relapse.

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MedXY Editorial Team•Aug 17, 2026•Hematology-Oncology

Myelodysplastic neoplasms (MDS) provoke profound spatial alterations in bone marrow microarchitecture beyond blast count abnormalities.
Multiplex immunofluorescence combined with single-cell phenotyping enables quantification of >5 million spatially resolved marrow cells in patients and controls.
A novel Microarchitectural Perturbation Score (MDS-MAPS) summarizes 82 architectural features, outperforming blast percentage in distinguishing active disease from remission and low-blast MDS from clonal cytopenia of undetermined significance.
MDS-MAPS dynamically tracks marrow remodeling during treatment, correlating with disease activity independently of blast burden and indicating tissue-state normalization or relapse.

MedXY registered readers

Create or use your MedXY account to unlock the complete article.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Open language-specific specialty feeds and department pages.

Loading comments...