Diabetes & EndocrinologyCaloric RestrictionIGF-1
Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2
By MedXY|May 13, 2026
CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.