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Hypoxic Microenvironment Triggers Early Aggressive Progression in EGFR-Mutant Lung Adenocarcinoma
By MedXY|Jun 29, 2026
This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance a