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Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY|May 18, 2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

Ketogenic Diet Shows Modest Short-Term Benefits in Treatment-Resistant Depression: A Critical Review of New Clinical Trial Evidence

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treatment-resistant depression

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Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

Ketogenic Diet Shows Modest Short-Term Benefits in Treatment-Resistant Depression: A Critical Review of New Clinical Trial Evidence

ANK3-Guided Liafensine Shows Clinically Meaningful Benefit in Treatment‑Resistant Depression: Results of the ENLIGHTEN Trial

Esketamine Monotherapy for Treatment-Resistant Depression: A New Therapeutic Frontier

Esketamine in Lung Cancer Patients with Major Depression: Efficacy for Smoking Cessation and Treatment-Resistant Depression

Pramipexole Augmentation in Treatment-Resistant Unipolar Depression: A UK Multicentre Randomised Trial