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This study reveals significantly reduced ACE protein levels in cerebrospinal fluid and serum of early-stage psychosis patients, particularly in treatment-resistant cases, highlighting a potential biomarker and mechanistic role beyond enzyma
A new narrative review synthesizing evidence from 1980 to 2025 argues that schizophrenia spectrum disorders cannot be explained solely by dopaminergic dysfunction. The authors propose a pluralistic model involving multiple neurochemical and cellular processes, with implications for treatment development and biomarker-based stratification.
New data reveal many patients with focal epilepsy experience seizures beyond the first treatment year, with nearly a quarter developing resistance to antiseizure medications, underscoring the need for optimized treatment strategies.
