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Tozorakimab

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Respiratory

Tozorakimab: A Promising Monoclonal Antibody to Reduce COPD Exacerbations

Tozorakimab, targeting interleukin-33, significantly reduces moderate to severe COPD exacerbations in former and current smokers despite standard inhaled therapy, offering a novel therapeutic approach with a favorable safety profile.

Nov 5, 2026
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Targeting IL-33 in COPD: Insights from the Phase 2a FRONTIER-4 Trial of Tozorakimab

The FRONTIER-4 phase 2a trial evaluated tozorakimab, an anti-IL-33 monoclonal antibody, in moderate-to-severe COPD with chronic bronchitis. While the primary endpoint was unmet in the overall population, efficacy signals emerged in patients

Sep 19, 2025

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